Exion RF Microneedling + Salmon-Sperm (PDRN), Rejuran & Exosomes — Why Dr. Hong Chooses This Combo

If you follow advanced skin-rejuvenation trends, you’ve probably heard about combining microneedling with radiofrequency (RF) and biologic serums. At Dr. H’s clinic we pair Exion RF microneedling with Korean PDRN (often called “salmon-sperm DNA”), Rejuran, and exosomes to get predictable improvement in texture, tone, laxity and glow. Below I’ll explain what each component does, why the combo is popular, and Dr. H’s practical 4-treatment recommendation.

What is Exion RF microneedling?

Exion RF is a device that delivers fractional radiofrequency energy through tiny needles. That combination does two important things:

The needles create controlled micro-channels — the classic microneedling stimulus — which triggers wound-healing and collagen production.
RF energy heats deeper dermal layers, tightening tissue and increasing collagen and elastin remodeling without overly damaging the epidermis.

Compared with needling alone, RF enhances tightening and gives more significant improvement in laxity and pore size.

What is “salmon-sperm” / PDRN / Rejuran?

“Salmon-sperm” is an informal way people describe PDRN (polydeoxyribonucleotide) — short DNA fragments extracted from salmon DNA. In aesthetic practice PDRN (marketed under names like Rejuran) is widely used as a skin booster because it:

Supports tissue repair by activating local regenerative pathways.
Encourages fibroblast activity and collagen formation.
Has anti-inflammatory and hydration benefits.
Is well tolerated (low immunogenicity) when sourced and processed correctly — which is why many clinicians prefer Korean PDRN products like Rejuran.

When applied into the skin after microneedling, PDRN can use the microchannels to penetrate more effectively and amplify healing.

What are Exosomes and how do they help?

Exosomes are tiny extracellular vesicles released by cells that contain signaling molecules (proteins, miRNA, lipids). In aesthetics, exosome products are used to:

Deliver regenerative signals to skin cells, modulating inflammation and promoting collagen synthesis.
Enhance cellular communication to support faster, more organized repair.
Improve overall skin quality, brightness and texture when combined with delivery methods like microneedling.

In short: think of exosomes as “cellular messengers” that tell your skin’s repair machinery to work smarter.

Why this combo works (synergy, not gimmick)

Microneedling + RF = mechanical + thermal stimulation → stronger collagen remodeling and tightening.
Microchannels created by needling significantly increase penetration of PDRN and exosomes.
PDRN/Rejuran provides building blocks and regenerative signaling that support the wound-healing cascade and improve hydration.
Exosomes amplify cell signaling for cleaner, faster regeneration and better quality collagen.
Together, they produce more durable improvement in texture, elasticity and radiance than any single treatment alone.

Why it’s popular

Visible improvement in skin texture, pore size, fine lines, and firmness with relatively short downtime.
Good compatibility with a wide range of skin types (when performed by experienced providers).
The “bio-boost” trend — patients want treatments that not only injure the skin for remodeling, but also supply regenerative factors to optimize results.
Increasing trust in Korean biotech skin boosters (Rejuran/PDRN) and exosome products has driven popularity in medical aesthetic clinics.

Dr. Hong’s protocol & 4-treatment recommendation

Dr. H uses Korean PDRN (Rejuran) as the primary biologic booster combined with Exion RF microneedling and a complementary exosome infusion for patients who want accelerated regenerative results.

Typical plan Dr. H recommends:

Series of 4 treatments spaced 3–4 weeks apart.

Why 4? It gives repeated stimulation to the collagen cycle and cumulative improvement in tone/texture.

Pre-treatment: skin prep (hydrafacial or gentle chemical exfoliation if appropriate) and topical numbing. Avoid active retinoids 3–5 days prior.
During treatment: Exion RF pass(es) followed by topical/needle-assisted application of Rejuran (PDRN) and then an exosome product into the microchannels or via mesotherapy depending on skin needs.
Maintenance: single maintenance session every 3–6 months depending on aging concerns and lifestyle.

Expected timeline: mild to moderate redness and swelling for 24–72 hours; ongoing skin improvement becomes noticeable after 2–4 weeks and continues to improve over 3 months as collagen matures.

Who is a good candidate — and who should wait?

Good candidates:

Patients with early-to-moderate skin laxity, large pores, uneven texture, fine lines, or dullness.
Those seeking improvement without surgical downtime.

Contraindications / caution:

Active skin infection, open wounds or herpes simplex in the treatment area.
Recent isotretinoin use (consult your provider).
Pregnancy or breastfeeding (many exosome and biologic products lack safety data).
Autoimmune conditions or history of keloids — individual evaluation required.

Aftercare & what to expect

Keep skin clean; use gentle cleanser and SPF.
Avoid strenuous exercise, saunas and heavy sweating for 48 hours.
Hydrating creams and gentle reparative serums are encouraged; avoid active acids for several days.
Expect gradual improvement: texture and radiance often improve first; tightening and collagen remodeling continue over 8–12 weeks.

Short FAQ

Q: How many sessions until I see results?
A: Many patients notice brighter skin after the first session; optimal results after the full 3–4 session course.

Q: Is it painful?
A: Most patients tolerate it well with topical numbing; sensations vary but are generally manageable.

Q: Are PDRN and exosomes safe?
A: When sourced and administered properly by trained clinicians, they have good safety profiles. Discuss product sourcing and testing with your provider.

Final note

Combining Exion RF microneedling with Korean PDRN (Rejuran) and exosomes is a powerful regenerative approach for modern skin rejuvenation. At Dr. H’s clinic we tailor energy settings, biologic dosages, and timing to each patient’s skin goals — the recommended 4-treatment series spaced 3–4 weeks apart gives a reliable balance of effectiveness and safety.